Principal Investigator
Dr. Ye-Guang Chen
Professor
Academician of the CAS
Principal Investigator
Dr. Ye-Guang Chen
Professor
Academician of the CAS
Research
Our group has long been dedicated to interdisciplinary investigations at the interface of cellular signaling and organoid technology. By integrating approaches from cell biology, molecular biology, bioinformatics, and genetics, and combining organoid systems with animal models and multi-omics analyses, we conduct systematic research centered on the following core areas:
Systematically investigate the regulatory mechanisms governing adult stem cell self-renewal and lineage-specific differentiation,
and identify key molecular targets that mediate stem cell-driven tissue homeostasis and injury repair.
Develop and optimize novel culture systems for multiple organoid types, including intestinal, gastric, pulmonary, hepatic, renal,
and pancreatic organoids, to enhance long-term stability and functional integrity.
Publications
Xiao YH*, Yu SC*, Zhang MX,
Zhong NS, Hua S, Fang Z, Zhang Z, Liu HD, Tan RH, Liu Y, Chen YG#. （2025） Crotonate enhances intestinal
regeneration after injury via HBO1-mediated H3K14 crotonylation, Nature
Communications, 16(1):8800.
Yu SC*, Li J*, Ye ZF, Zhang
MX, Guo XH, Wang X, Liu LS, Wang YL, Zhou X, Fu W, Zhang Michael, Chen YG#. （2025）Identification of a
10-species microbial signature of inflammatory bowel disease by machine
learning and external validation, Cell Regeneration, 14(1):32.
Wang X*, Li SQ*, Liu Y*,
Kuang XY, Chen JX, Yu P, Zhao LZ, Zhang Z, Huang MM, Liu LS, Zhang MX, Wang YL,
Ji WZ, Li JS, Zhang L, Chen YG#.
（2025）Positional
BMP signaling orchestrates villus length in the small intestine, Nature Communications,
16(1):5461.
molcell@tsinghua.edu.cn
010-62784794