科研成果

发表论文 专著专利 成员荣誉
2025
Xiao YH*, Yu SC*, Zhang MX, Zhong NS, Hua S, Fang Z, Zhang Z, Liu HD, Tan RH, Liu Y, Chen YG#. （2025） Crotonate enhances intestinal regeneration after injury via HBO1-mediated H3K14 crotonylation, Nature Communications, 16(1):8800.
Yu SC*, Li J*, Ye ZF, Zhang MX, Guo XH, Wang X, Liu LS, Wang YL, Zhou X, Fu W, Zhang Michael, Chen YG#. （2025）Identification of a 10-species microbial signature of inflammatory bowel disease by machine learning and external validation, Cell Regeneration, 14(1):32.
Wang X*, Li SQ*, Liu Y*, Kuang XY, Chen JX, Yu P, Zhao LZ, Zhang Z, Huang MM, Liu LS, Zhang MX, Wang YL, Ji WZ, Li JS, Zhang L, Chen YG#. （2025）Positional BMP signaling orchestrates villus length in the small intestine, Nature Communications, 16(1):5461.
Hua S,  Zhang Z, Zhang Z, Liu LS, Yu SC, Xiao YH, Liu Y, Wei ST, Xu Y, Chen YG#. （2025）Genetic disruption of the circadian gene Bmal1 in the intestinal epithelium alleviates colonic inflammation, EMBO Reports, 26(12):3138.
Liu ZN, Li CL, Huang MM, Chen YG#, Liu Y#. (2025) YTHDF2-KIF26B-Wnt signaling forms a positive-feedback regulatory loop to maintain ISC stemness, Cell Regeneration, 14(1):26.
Li LL, Zhang Z, Wang X, Zhao HY, Liu LS, Xiao YH, Hua S, Chen YG#. （2025）PRMT5 maintains homeostasis of the intestinal epithelium by modulating cell proliferation and survival,  Advanced Science, e2415559.
Hong F*, Wang XD*, Zhong NS, Zhang Z, Lin SB, Zhang MX, Li HN, Liu Y, Wang YL, Zhao LZ, Yang X, Zhou HW, Liang H, Chen YG# (2025) The critical role of BMP signaling in gastric epithelial cell differentiation revealed by organoids, Cell Regeneration, 14(1):18.
Liu HD, Chen YG#. （2025）Spermine attenuates TGF-β-induced EMT by downregulating fibronectin, Journal of Biological Chemistry, 301(4):108352.
Li LL, Xiao YH, Liu LS, Zhang QY, Zhang Y, Zhu DH, Chen YG#. （2025）eIF5A maintains intestinal epithelial homeostasis by sustaining intestinal stem cells, Cell Regeneration, 14(1):23.
Zhong NS, Zhang ZF, Fang Z, Chen YG#, Wang YL# . (2025) Application of Intestinal Organoid Transplantation in Regenerative Medicine. Ke Xue Magazine 77(05):40.

Hong F*, Tan RH*, Wang T*, Zhong NS*, Zhao HL, Xu RH, Shen L, Liu YB, Yao XB, Xiang DX, Hui LJ, Xiong JP, Gao D, Zhao B, Miao ZF, Hao J, Li Y, Hu SJ, Fu BQ, Hua GQ, Wang L, Zeng ZL, Chen C, Wu JM, Wang CL, Wang CN, Zhan XB, Song C, Yu CP, Yang YY, Niu GM, Wang YL#, Zhao TB#, Chen YG# (2025) Standard: Human gastric cancer organoids, Cell Regeneration, 14(1):2.(Review).
Yang L, Wang S, Qiao Z, Liu Y, Wang Xu, Liu L, Yang C, Ding J, Lei M, Zheng J, Hu W, Chen YG, Chan YS#. (2025) Dual-ligand engineered exosome regulates WNT signaling activation to promote liver repair and regeneration. Nature Communications, 16(1):9019.
Hou J, Song Y, Xiao C, Sun Y, Shen J, Ma X, Zhou Q, Chiu S, Xu Y, Huang Y, Chen YG, Zhu X, Wang JB#, Xiong JW#. (2025) Cloche/Npas4l is a pro-regenerative platelet factor during zebrafish heart regeneration. Developmental Cell, 60(21):2897.
Pei Y, Fang M, Wu H, Cui Q, Quan L, Li X, Zhang K, Xie P, Jiang P, Liu Y, Huang MM, Lv F, Hu X, Chen YG, Hu XL#, Xiao RP#. (2025) Mitsugumin 53 drives stem cell differentiation easing intestinal injury and inflammation. Signal Transduction and Targeted Therapy, 10(1):183. 
Xu HK, Wang YB, Wang WY, Fu YX, Qiu J, Shi Y, Yuan L, Dong C, Hu XY, Chen YG, Guo XH#. (2025) ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling. Science Immunol, 10(107):eadn1491.
2024
Li YH*, Wang XD*, Huang MM*, Wang X, Li CL, Li SQ, Tang YH, Yu SC, Wang YL, Song WL, Wu W, Liu Y#, Chen YG#. （2024）BMP balances Wnt signaling via the Bcl11b-1 regulated NuRD complex to maintain intestinal stem cells, EMBO Journal, 43(23):6032.
Shi QN, Huang F, Wang YL, Deng HT, Chen YG#.（2024）HER2 phosphorylation induced by TGF-β promotes mammary morphogenesis and breast cancer progression. Journal of Cell Biology, 223(4):e202307138.
Cui YZ*, Shi QN*, Song P, Tong JY, Cheng ZM, Zhang HC, Wang XD, Zheng YX, Wu Y, Wan M, Li SH, Zhao X, Tong Z, Yu ZQ, Gao S#, Chen YG#, Gao F#. (2024) Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling, Journal of Experimental Medicine, 221 (8): e20231512.
Lou RY, Song WL, Yu SC, Wang XD, Liu Y, Chen YG#, Wang YL#. (2024)Identification of feature genes in intestinal epithelial cell types, Cell Regeneration, 13(1):24.
Nong JX*, Shen SQ*, Hong F, Xiao F, Meng LT, Li PL, Lei XG#, Chen YG#. （2024）Verteporfin inhibits TGF-β signaling by disrupting the Smad2/3–Smad4 interaction. Molecular Biology of the Cell, 35(7):ar95.
Wang Y*, Huang MM*, Mu XY*, Song WL, Guo Q, Zhang M, Liu Y#, Chen YG#, Ge L#. (2024) TMED10-mediated unconventional secretion of IL-33 regulates intestinal epithelium differentiation and homeostasis, Cell Research, 34(3):258.
Tan RH*, Zhang Z*, Ding PR*, Liu Y, Liu HD, Lu MY, Chen YG#.（2024）A growth factor-reduced culture system for colorectal cancer organoids. Cancer Letters, 588:216737.
Wang T*, Song WL*, Meng QY*, Qu CQ, GuoSH, Wang YL, Tan RH, Jia BQ#, Chen YG#. （2024）Tumorigenicity and prediction of clinical prognosis chemotherapy response of patient-derived gastric cancer organoids. Clinical and Translational Medicine, 14(2):e1588.
Huang MM*, Wang XD*, Zhang MX, Liu Y#, Chen YG#. （2024）METTL3 restricts RIPK1-dependent cell death via the ATF3-cFLIP axis in the intestinal epithelium. Cell Regeneration, 13(1):14.
Xiang DX*, He AN*, Zhou R*, Wang YG*, Xiao XY*, Gong T*, Kang WY*, Lin XL*, Wang XC*, DST Consortium, Liu LX#, Chen YG#, Gao SR#, Liu YB#.（2024）Building  consensus on the application of organoid-based drug sensitivity testing in cancer precision medicine and drug development, Theranostics, 14(8):3300. (Review)(#Co-corresponding) .
Wang YL*, Tan RH*, Chen YG#.（2024） Organoid Culture of Different Intestinal Segments from Human and Mouse. Methods in Molecular Biology, 2951:47.(Review).
Liu Y，Wang YL，Cai JL，Chen YG#.（2024） Development and Application of Organoids，Ke Xue Magazine，2024,76(02) (Review).

Tan RH*, Hong F*, Wang T*, Zhong NS*, Zhao HL, Xu RH, Shen L, Liu YB, Yao XB, Xiang DX, Gao D, Xiong JP, Hui LJ, Zhao B, Miao ZF, Hao J, Li Y, Hu SJ, Fu BQ, Hua GQ, Wang L, Zeng ZL, Chen C, Wu JM, Wang CL, Wang CN, Zhan XB, Song C, Sun ZJ, Yu CP, Yang YY, Niu GM, Wang YL#, Zhao TB#, Chen YG# (2024) Standard: Human gastric cancer organoids, Cell Regeneration, 13(1):33. (Review).
Li YH#, Zhang MX, Ma XR, Chen YG.  (2024) Tuft cells promote human intestinal epithelium regeneration as reserve stem cells after irradiation. Cell Regeneration, 13(1):28.
Díaz-Carballo D, Safoor A, Saka S, Noa-Bolaño A, Souza F, Klein J, Acikelli A, Malak S, Rahner U, Turki A, Höppner A, Kamitz A, Song WL, Chen YG, Kamada L, Tannapfel A, Brinkmann S, Ochsenfarth S, Strumberg D#. (2024) The neuroepithelial origin of ovarian carcinomas explained through an epithelialmesenchymal-ectodermal transition enhanced by cisplatin, Scientific Reports, 14(1):29286.
Gu SC, Rik Derynck, Chen YG, Feng XH#. (2024) New progress in roles of TGF-β signaling crosstalks in cellular functions, immunity and diseases. Cell Regeneration, 13(1):11
Hou JJ, Chen YG, Xiong JW#. (2024) Unveiling new horizons in heart research: the promise of multi-chamber cardiac organoids. Cell Regeneration, 13(1):10.
Zhang C, Wei W, Tu S, Liang B, Li C, Li Y, Luo W, Wu Y, Dai X, Wang Y, Zheng L, Hao L, Zhang C, Luo Z, Chen YG, Yan XH#. (2024) Upregulation of CYR61 by TGF-β and YAP signaling exerts a counter-suppression of hepatocellular carcinoma. Journal of Biological Chemistry, 300(4):107208.
Hu XL, Chen FY, Jia LJ, Long AJ, Peng Y, Li X, Huang JF, Wei XY, Fang XL, Gao ZX, Zhang MX, Liu X, Chen YG, Wang Y, Zhang HJ#, Wang YG#. (2024) A gut-derived hormone regulates cholesterol metabolism. Cell, S0092-8674(24)00226-5.
Huang J, Zhang X, Xu H, Liu Y, Zhao J, Huang J, Song Z, Zhu M, Fu Y, Chen YG, Guo XH#. (2024) Intraepithelial Lymphocytes Promote Intestinal Regeneration through CD160/HVEM Signaling. Mucosal Immunol, S1933-0219.
2023
Wang YL*, Lou RY*, Zhang Z, Xiao CY, Yu SC, Wei ST, Liu Y, Fu W, Li BJ,  Chen YG#. (2023) Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17, Science Advances, 9(43):eadi1827.
Wei XY , Yu SC, Zhang TH, Liu LS, Wang X, Wang XD, Chan YS, Wang YM, Meng S, Chen YG#. (2023) MicroRNA-200 loaded lipid nanoparticles promote intestinal epithelium regeneration in canonical microRNAs-deficient mice, ACS Nano, 17(22):22901.
Liu LS*, Wang YL*, Yu SC*, Liu HD, Li YH, Hua S, Chen YG#. (2023) TGF-β promotes inflammation and tumorigenesis in Smad4-deficient intestinal epithelium in a YAP-dependent manner, Advanced Science, 10(23):e2300708.
Wei ST*, Li M*, Song WL, Liu JY, Yu SC, Wang YL, Zhang MX, Du HJ, Liu Y,  Liu HD, Fu W, Li BJ, Chen YG#. (2023) The cyclooxygenase-expressing mesenchyme resists intestinal epithelial injury by paracrine signaling. Cell Regeneration. 12(1):30.
Liu Y*, Huang MM*, Wang XD*, Liu ZN, Li SQ, Chen YG#. (2023) Segregation of the stemness program from the proliferation program in intestinal stem cells, Stem Cell Reports, 18(5):1196
Wang XD*, Hong F*, Li HN, Wang YL, Zhang MX, Lin SB, Liang H, Zhou HW, Liu Y, Chen YG#. (2023) Cross-species Single-cell Transcriptomic Analysis of Animal Gastric Antrum Reveals Intense Porcine Mucosal Immunity. Cell Regeneration. 12(1):27.
Yu SC, Zhang MX, Ye ZF, Wang YL, Wang X, Chen YG#. (2023) Development of a 32-gene signature using machine learning for accurate prediction of infammatory bowel disease,  Cell Regeneration, 12(1):8. 
Lin HQ*, Wang YL*, Chen CY*, Qian YX*, Hao J, Zhang Z, Sheng WQ, Song LH, Deng CX, Zhao B, Cao JN, Wang L, Wang L, Liang LM, Chen WL, Yu CP, Sun ZJ, Yang YY, Wang CL, Zhang Y, Li QY, Li K, Ma AJ#, Zhao TB#, Chen YG#, Hua GQ#.(2023) Standard: Human intestinal cancer organoids, Cell Regeneration, 12(1):24. (Review) (#Co-corresponding) .
Wang YL*, Lin HQ*, Zhao LZ*, Hong F*, Hao J, Zhang Z, Sheng WQ, Song LH, Deng CX, Zhao B, Cao JN, Wang L, Wang L, Liang LM, Chen WL, Yu CP, Sun ZJ, Yang YY, Wang CL, Zhang Y, Li QY, Li K, Ma AJ#, Zhao TB#, Hua GQ#, Chen YG#. (2023) Standard: Human intestinal organoids, Cell Regeneration, 12(1):23.  (Review).
Xiang JN, Guo JG, Zhang SY, Wu HG, Chen YG, Wang JP, Li BJ, Liu HJ#. (2023) A stromal lineage maintains crypt structure and villus homeostasis in the intestinal stem cell niche, BMC Biology, 21(1):169.
Chen LM, Xie XS, Wang TT, Xu LL, Zhai ZY, Wu HB, Deng LB, Lu QQ, Chen ZJ, Yang X, Lu H, Chen YG, Luo SW#. (2023) ARL13B promotes angiogenesis and glioma growth by activating VEGFA-VEGFR2 signaling, Neuro-Oncology, 25(5):871.
2022
Kang KX*, Shi QN*, Wang X, Chen YG#. (2022)  Dishevelled  phase separation promotes Wnt signalosome assembly and destruction complex disassembly, Journal of Cell Biology, 221(12):e202205069.
Zhao LZ, Liao HW, Wang XD, Chen YG#. (2022) DDB1 maintains intestinal homeostasis by preventing cell cycle arrest. Cell Regeneration, 11(1):18.
Zhao LZ*, Song WL*, Chen YG#. (2022) Mesenchymal-epithelial interaction regulates gastrointestinal tract development in mouse embryos. Cell Reports, 40(2):111053.
Li HN*, Wang XD*, Wang YL, Zhang MX, Hong F, Wang H, Cui A, Ji WZ, Chen YG#. (2022) Cross-species single-cell transcriptomic analysis reveals divergence of cell composition and functions in mammalian ileum epithelium. Cell Regeneration, 11(1):19.
Liu HD, Chen YG#. (2022) The Interplay Between TGF-β Signaling and Cell Metabolism. Frontiers in Cell and Developmental Biology, 10: 846723. (Review)
Wang YL*, Song WL*, Yu SC, Liu Y, Chen YG#. (2022) Intestinal cellular heterogeneity and disease development revealed by single-cell technology，Cell Regeneration, 11(1):26. (Review).
Beumer J, Puschhof J, Yengej FY, Zhao LZ, Martinez-Silgado A, Blotenburg M, Begthel H, Boot C, van Oudenaarden A, Chen YG, Clevers H#. (2022) BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states. Cell Reports, 38(9):110438.
2021
Nong JX*, Kang KX*, Shi QN*, Zhu XC, Tao QH, Chen YG#.  (2021)  Phase separation of Axin organizes the β-catenin destruction complex.  Journal of Cell Biology, 220(4): e202012112.
Wang S*, Li SQ*, Li YH*, Jiang QL, Li XT, Wang YL, Han JD, Liu Y#, Chen YG#, (2021) Non-muscle myosin heavy chain 9 maintains intestinal homeostasis by preventing epithelium necroptosis and colitis adenoma formation, Stem Cell Reports, 16(5):1290.
Wang T*, Zhang N*, Fan SP*, Zhao LZ*, Song WL*, Gong YH, Shen Q, Zhang C, Ren P, Lin CT, Fu W, Gao G, Ma SH#, Bi YH#, Chen YG#.  (2021)  Establishment of human distal lung organoids for SARS-CoV-2 infection. Cell Discovery, 7(1):108.
Zhou Q#, Chen W, Fan Z, Chen Z, Liang J, Zeng G, Liu L, Liu W, Yang T, Cao X, Yu B, Xu M, Chen YG#, Chen L#. (2021) Targeting hyperactive TGFBR2 for treating MYOCD deficient lung cancer. Theranostics, 11(13):6592.
Yan Z, Cheng MZ, Hu G, Wang Y, Zeng S, Huang A, Xu L, Liu Y, Shi C, Deng L, Lu Q, Rao H, Lu H, Chen YG#, Luo SW#. (2021) Positive feedback of SuFu negating protein 1 on Hedgehog signaling promotes colorectal tumor growth. Cell Death & Disease, 12(2):199.
Li HN, Wang YL, Zhang MX, Wang H, Cui AL, Zhao JG, Ji WZ, Chen YG#.  (2021)  Establishment of porcine and monkey colonic organoids for drug toxicity study. Cell Regeneration, 10(1):32.
Shi QN, Chen YG#. (2021) Regulation of Dishevelled protein activity and stability by post-translational modifications and autophagy, Trends in Biochemical Sciences, S0968-0004(21)00167-5. (Review).
Shi QN*, Kang KX*, Chen YG#. (2021) Liquid–liquid phase separation drives the β-catenin destruction complex formation, BioEssays, 43(10):e2100138.  (Review).
Fu X*, He Q*, Tao Y*, Wang M*, Wang W*, Wang YL*, Yu Q*, Zhang F*, Zhang X*, Chen YG#, Gao D#, Hu P#, Hui L#, Wang X#, Zeng Y#. (2021). Recent advances in tissue stem cells. Science China Life Science , 64(12):1998. (Review)(#Co-corresponding) .
Wang T, Fan SP, Chen YG#. （2021）. Organoids: a new research model for SARS-CoV-2 infection and treatment. Science China: Life Science,  51.
Gao L, Yu Q, Zhang H, Wang Z, Zhang Z, Zhang T, Xiang J, Yu S, Zhang S, Wu H, Xu Y, Wang Z, Shen L, Shu G, Chen YG, Liu HJ#, Shen L#, Li BJ#. (2021) A resident stromal cell population actively restrains innate immune response in the propagation phase of colitis pathogenesis in mice. Science Translational Medicine, 13(603):eabb5071.
Niu MM; He YJ; Xu J; Ding LP; He T; Yi Y; Fu MY; Guo RT; Li FT; Chen H; Chen YG; Xiao ZX#. (2021)  Noncanonical TGF-β signaling leads to FBXO3-mediated degradation of Delta Np63 alpha promoting breast cancer metastasis and poor clinical prognosis. Plos Biology, 19(2): e3001113.
Yu ZY, Zeng J, Wang J, Cui YX, Song XP, Zhang YZ, Cheng X, Hou N, Teng Y, Lan Y, Chen YG, Yang X#. (2021) Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability. Cardiovascular Research, 117(2):533.
2020
Wang YL*, Song WL*, Wang JL, Wang T, Xiong XC, Qi Z, Fu W#, Yang XR#, Chen YG#. (2020) Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. Journal of Experimental Medicine, 217(2). pii: e20191130.
Liao HW*, Li X*, Zhao LZ*, Wang YL, Wang XD, Wu Y, Zhou X, Fu W, Liu L, Hu HG#, Chen YG#. (2020) A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer. Cell Discovery, 6(35):1
Zhao LZ, Wang XD, Kumpanat Pomlok, Liao HW, Yang G, Yang X, Chen YG#. (2020) DDB1 promotes the proliferation and hypertrophy of chondrocytes during mouse skeleton development. Developmental Biology, 465(2):100.
Liu Y, Chen YG#. (2020) Intestinal epithelial plasticity and regeneration via cell dedifferentiation, Cell Regeneration, 9(1):14. (Review).
Liu Y, Xiong XC, Chen YG#. (2020) Dedifferentiation: the return road to repair the intestinal epithelium, Cell Regeneration, 9(1):2. (Review).
Zhang MX, Liu Y, Chen YG#. (2020) Generation of 3D Human Gastrointestinal Organoids: Principle and Applications, Cell Regeneration, 9(1):6. (Review).
Chen YG#, Lou Y. (2020) Welcome to Cell Regeneration. Cell Regeneration, 9(1):1. (Review).
He D, Wu HG, Xiang JN, Ruan XS, Peng PK, Ruan YY, Chen YG, Wang YB, Yu Q, Zhang HB, Habib S, Pinho R, Liu HJ#, Li BJ#. (2020)  Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway, Nature Communications, 11(1):37.
Liu L, Wu YD, Zhang C, Zhou C, Li YN, Zeng Y, Zhang CB, Li R, Luo DY, Wang LL, Zhang L, Tu S, Deng H, Luo SW, Chen YG, Xiong XY#, Yan XH#.  (2020) Cancer-associated adipocytes-derived G-CSF promotes breast cancer malignancy via Stat3 signaling. Journal of Molecular Cell Biology, 12(9):723.
Lai SS, Chen R, Gao D, Chen YG, Deng C#. (2020) LGR5 constitutively activates NF-κB signaling to regulate the growth of intestinal crypts. FASEB Journal, 34(11):15605.
Liu L, Li T, Liao Y, Wang Y, Gao Y, Hu H, Huang H, Wu F, Chen YG, Xu S, Fu S. (2020) Triose Kinase Controls the Lipogenic Potential of Fructose and Dietary Tolerance. Cell Metabolism, 32:605.
2019
Li YZ*, Liu Y*, Y. Jeffrey Chiang, Huang F, Li YH, Li XT, Ning YH, Zhang WH, Deng HT, Chen YG#.  (2019)  DNA Damage Activates TGF-β Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor TβRII.  Cell Reports, 28(3):735
Shi QN, Chen YG#. (2019) ALK-mediated Tyr95 phosphorylation of Smad4 impairs its transcription activity and the tumor suppressive activity of TGF-β.  Science China-Life Sciences, 62(3):431
Shi QN, Chen YG#.  (2019)  The functional switch of TGF-β signaling in breast cancer.  Oncotarget, 10(17):1604-1605.  (Review).
Qi Z, Chen YG# (2019) Efficient culture of intestinal organoids with blebbistatin. Methods in Molecular Biology,1576:113.(Review).
Chen YG, Lou Y. 2019 Relaunching of Cell Regeneration. Cell Regeneration, 8(2):31-32. (Editorial).
Luo MG, Bai JB, Liu BF, Yan PQ, Zuo FF, Sun HY, Sun Y, Xu XH, Song ZH, Yang Y, Joan Massague, Lan X, Lu Z, Chen YG, Deng HT, Xie W, Xi QR#,  (2019) H3K18ac Primes Mesendodermal Differentiation upon Nodal Signaling,  Stem Cell Reports, 13(4):642.
2018
Xu X, Wang L, Liu B, Xie W, Chen YG#. (2018) Activin/Smad2 and Wnt/β-catenin upregulate HAS2 and ALDH3A2 to facilitate mesendoderm differentiation of human ESCs. Journal of Biological Chemistry, 293(48):18444.
Ye P, Chiang YJ, Qi Z, Li Y, Wang S, Liu Y, Li X, Chen YG#. (2018) Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death. PLoS Genetics. 14(9):e1007697.
Li YH, Liu Y, Liu B, Wang J, Wei S, Qi Z, Wang S, Fu W, Chen YG#. (2018) A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5+ intestinal stem cell maintenance. Cell Discovery, 4:49.
Huang F*, Shi Q*, Li Y, Xu L, Xu C, Chen F, Wang H, Liao H, Chang Z, Liu F, Zhang XH, Feng XH, Han JJ, Luo S, Chen YG#. (2018) HER2/EGFR-AKT signaling switches TGF-β from inhibiting cell proliferation to promoting cell migration in breast cancer. Cancer Research, 78(21):6073. 
Liu Y, Qi Z, Li X, Du Y, Chen YG#. (2018) Monolayer culture of intestinal epithelium sustains Lgr5+ intestinal stem cells. Cell Discovery, 4:32.
Liu Y, Chen YG#. (2018) 2D- and 3D-Based Intestinal Stem Cell Cultures for Personalized Medicine. Cells, 7(12). pii:E225. (Review).
Wang S, Chen YG#. (2018) BMP signaling in homeostasis, transformation and inflammatory response of intestinal epithelium. Science China Life Science, 61(7):800-807. (Review).
Yan X#, Xiong X, Chen YG#.  (2018)  Feedback regulation of TGF-β signaling. Acta Biochimica et Biophysica Sinica, 50(1):37. (Review).
2017
Wu Y*, Li Y*, Li X, Zou Y, Liao H, Liu L, Chen YG#, Bierer D#, Hu H#.  (2017)  A novel peptide stapling strategy enables the retention of ring-closing amino acid side chains for the Wnt/b-catenin signalling pathway,  Chemical Science, 8(11): 7368
Yan X#*, Wu J*, Jiang Q, Cheng H, Han J, Chen YG#.  (2017)  CXXC5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosis. Journal of Molecular Cell Biology. 10(1):48
Qi Z*, Li Y*, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han J, Chen YG#. (2017) BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes. Nature Communications, 8:13824.
Wang L*, Xu X*, Cao Y, Li Z, Cheng H, Zhu G, Duan F, Na J, Han JD, Chen YG#. (2017) Activin/Smad2-induced H3K27me3 reduction is crucial to initiate mesendoderm differentiation of human embryonic stem cells. Journal of Biological Chemistry, 292(4):1339.
Shi QN, Chen YG#. (2017) Interplay between TGF-β signaling and receptor tyrosine kinases in tumor development.  Science China Life Sciences, 60(10):1133.  (Review).
Hata A#, Chen YG#. (2017)  TGF-β Signaling from Receptors to Smads. Cold Spring Harbor Perspectives in Biology, 8(9):1-32. (Review).
Xu XH，Chen YG#.  (2017)  Regulation of Mesendoderm differentiation of embryonic stem cells，Chinese Bulletin of Life Sciences, 27(10):1016.  (Review).
Wang J, Qi Z, Li Y, Zhao H, Chen YG, Fu W#. (2017) TGFβ induced factor homeobox 1 promotes colorectal cancer development through activating Wnt/β-catenin signaling. Oncotarget.   8(41):70214.
Yu Y, Gu S, Li W, Sun C, Chen F, Xiao M, Wang L, Xu D, Li Y, Ding C, Xia Z, Li Y, Ye S, Xu P, Zhao B, Qin J, Chen YG, Lin X, Feng XH#. (2017) Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling. Proc Natl Acad Sci. USA. 114(38):10113.
Lin H, Ying Y, Wang Y, Wang G, Jiang S, Huang D, Luo L, Chen YG, Gerstenfeld C, Luo ZJ#. (2017) AMPK Downregulates ALK2 via Increasing the Interaction between Smurf1 and Smad6, leading to inhibition of in vitro Osteogenic Differentiation. BBA Molecular Cell Research. 1864(12):2369.
2016
Cheng MZ*, Xue H*, Cao WP, Li WX, Chen H, Liu BF, Ma BY, Yan XH, Chen YG#. (2016) RACK1 promotes Dishevelled degradation via autophagy and antagonizes Wnt signaling. Journal of Biological Chemistry, 291(24):12871
Yan X#, Liao H, Cheng M, Shi X, Lin X, Feng X, Chen YG#.  (2016)  Smad7 Interacts with R-Smads to Inhibito TGF-beta/Smad Signaling.  Journal of Biological Chemistry, 291(1):382
Wang L, Chen YG#.  (2016)  Signaling Control of Differentiation of Embryonic Stem Cells toward Mesendoderm. Journal of Molecular Biology, 428(7):1409
2015
Zhao B*, Qi Z*, Li Y*, Wang C, Fu W and Chen YG#. (2015)  Non-muscle-myosin-II mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells via the Rac1-PAK1-Akt axis. Nature Communications, 6:7166.
He K, Yan X, Li N, Dang S, Xu L, Zhao B, Li Z, Lv Z, Fang X#, Zhang Y#, Chen YG#. (2015) Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes. Cell Research.  25:738
Zhu G, Fei T, Li Z, Yan X, Chen YG#.  (2015)  Activin regulates self-renewal and differentiation of trophoblast stem cells by down-regulating the X-chromosome gene Bcor. Journal of Biological Chemistry, 290(36):22019.
Ma B*, Liu B*, Cao W, Gao C, Qi Z, Ning Y, and Chen YG#.  (2015)  The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy. Journal of Biological Chemistry, 290(19):12346.
Du J*, Hong S*, Dong L, Cheng B, Lin L, Zhao B, Chen YG#, Chen X#.  (2015)  Dynamic Sialylation in TGF-β-Induced Epithelial to Mesenchymal Transition. Journal of Biological Chemistry, 290(19):12000.
Huang Y, Wang P, Chen H, Ding Y, Chen YG#.  (2015)  Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation. Biochemical Journal, 466:499.
Qi Z, Chen YG#.  (2015)  Regulation of intestinal stem cell fate specification.  Science China Life Sciences. 58(6)570.  (Review)
Lin L, Liu L, Zhao B, Xie R, Lin W, Li H, Li Y, Shi M, Chen YG, Springer TA, Chen X. (2015) Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light. Nature Nanotechnology, 10:465.
Sun G, Hu Z, Min Z, Yan X, Guan Z, Su H, Fu Y, Ma X, Chen YG, Tao Q, Wu W. (2015) Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor (TGF)-mediated Germ Layer Induction in Xenopus Embryos.  Journal of Biological Chemistry, 290(28):17239.
2014
Ma BY*, Cao WP*, Li WX, Gao C, Qi Z, Zhao Y, Du J,  Xue H, Peng JY, Wen J,  Chen H, Ning YH,  Huang L, Zhang H, Gao X, Yu L, Chen YG# .  (2014)  Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation, Cell Research, 24(8):912.
Zhang Y*, Ding Y*, Chen YG#, Tao QH#. (2014)  NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling. Developmental Biology, 392:15.
Zuo W, Chen YG#. (2014) TGF-β signaling in hematopoietic stem cells and leukemia. Cancer Hallmarks, 1:91-97. (Review).
Zhao B, Chen YG#  (2014) Regulation of TGF-β signaling. Scientifica, 2014:874065. (Review).
Li Y, Wu H, Wu W, Zhuo W, Liu WX, Zhang YX, Cheng MZ, Chen YG, Gao N, Yu HT, Wang LF, Li W, Yang MJ#. (2014) Structural insights into the TRIM family of ubiquitin E3 ligases. Cell Research, 24:762.
Xu PF*, Zhu GY*, Wang Y, Sun J, Liu X, Chen YG, Meng AM#. (2014) Maternal Eomesodermin regulates zygotic nodal gene expression for mesendoderm induction in zebrafish embryos.  Journal of Molecular Cell Biology,  6(4), 272.
Yan X#, Pan J, Xiong W, Cheng M, Sun Y, Zhang S, Chen YG. (2014) Yin Yang 1 (YY1) synergizes with Smad7 to inhibit TGF-β signaling in the nucleus. Science China-Life Sciences, 57(1): 128.
Ding Y, Su S, Tang W, Zhang X, Chen S, Zhu G, Liang J, Wei W, Guo Y, Liu L, Chen YG, Wu W#. (2014) The S-G2 phase enriched β-catenin/TCF complex ensures cell survival and cell cycle progression. Journal of Cell Science, 127(22):4833.
Luo W, Xia T, Xu L, Chen YG, Fang X#. (2014) Visualization of the post-Golgi vesicle-mediated transportation of TGF-β receptor II by quasi-TIRFM. Journal of Biophotonics, 7(10):788.
2013
Xue H, Xiao ZC, Zhang J, Wen J, Wang Y, Chang Z, Zhao J, Gao X, Du J, Chen YG#. (2013) Disruption of the Dapper3 Gene Aggravates Ureteral Obstruction-mediated Renal Fibrosis by Amplifying Wnt/β-catenin Signaling, Journal of Biological Chemistry, 288(21): 15006
Tao R, Xue H, Zhang J, Liu J, Deng H, Chen YG#.  (2013)  The deacetylase Rpd3 facilitates checkpoint adaptation by preventing Rad53 over-activation. Molecular and Cellular Biology, 33(21):4212
Zhang J, Fei T, Li Z, Zhu G, Wang L, Chen YG#. (2013)  BMP induces cochlin expression to facilitate self-renewal and suppress neural differentiation of mouse embryonic stem cells. Journal of Biological Chemistry, 288(12):8053
Zuo W*, Huang F*, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG#.  (2013)  c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.  Molecular Cell, 49(3):499.
Ding Y*, Zhang Y*, Xu C, Tao Q#, Chen YG#. (2013)  HECT Domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting Dishevelled for proteasomal degradation. Journal of Biological Chemistry, 288(12): 8289.
Cui HK*, Zhao B*, Li Y, Guo Y, Hu H, Liu L#, Chen YG#.  (2013)  Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling. Cell Research, 23(4): 581.
Li Z, Chen YG#.  (2013) Functions of BMP Signaling in embryonic stem cell fate determination. Experimental Cell Research, 319(2):113.  (Review).
Yu L，Chen YG.  (2013) The 2013 Nobel Prize in Physiology or Medicine - for the Elucidation of the Molecular Mechanisms of Vesicle Trafficking, China Biotechnology，33(11):118. (Review).
Conidi A, van den Berghe V, Leslie K, Stryjewska A, Xue H, Chen YG, Seuntjens E, Huylebroeck D. (2013) Four amino acids within a tandem QxVx 1 repeat in a predicted extended α-2 helix of the Smad-binding domain of Sip1 are necessary for binding to activated Smad proteins. PLoS One, 8(10): e76733.
Liu X, Xiong C, Jia S, Zhang Y, Chen YG, Wang Q, Meng A#. (2013) Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm induction and patterning by directly phosphorylating Smad2 linker. Nature Communications, 4:1-11.
Zhao M, Yang X, Fu Y, Wang H, Ning Y, Yan J, Chen YG, Wang G#. (2013)  Mediator MED15 modulates TGFβ/Smad signaling and breast cancer cell metastasis. Journal of Molecular Cell Biology, 5(1):57-60.
Margariti A, Li H, Chen T, Martin D, Vizcay-Barrena G, Alam S, Karamariti E, Xiao Q, Zampetaki A, Zhang Z, Wang W, Jiang Z, Gao C, Ma B, Chen YG, Cockerill GW, Hu Y, Xu Q, Zeng L#.  (2013) XBP1 mRNA splicing triggers an autophagic response In endothelial cells through Beclin-1 transcriptional activation. Journal of Biological Chemistry, 288(2):859-872.
Yu J, He X, Chen YG, Hao Y, Yang S, Wang L, Pan L, Tang H#.  2013 Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins. Journal of Biological Chemistry, 288(1):79-88.
2012
Li Z*, Fei T*, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG#.  (2012)  BMP4 Signaling Acts via Dual Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells. Cell Stem Cell, 10:171.
Zhao B, Wang Q, Du J, Luo S, Xia J, Chen YG#.   (2012) PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor, Cell Research, 22(10):1467.
Shi Y*, Ding Y*, Lei YP, Yang XY, Xie GM, Wen J, Cai CQ, Li H, Chen Y, Zhang T, Wu BL, Jin L, Chen YG#, Wang HY#.  (2012)  Identification of novel rare mutations of DACT1 in human neural tube defects. Human Mutation, 33(10):1450. (#Co-corresponding)
Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JD, Bu G, Reed J, Liao FF, Chen YG#, Xu H#.    (2012)  Appoptosin is a novel proapoptotic protein and mediates cell death in neurodegeneration. Journal of Neuroscience, 32(44):155565.(#(Co-Corresponding).
Yan X#, Zhang JY, Sun QY, Polygena T, Wu XP, Jolinda A Chen YG#.  (2012)  p21-activated Kinase 2 (PAK2) Inhibits TGF-β Signaling in Madin-Darby Canine Kidney (MDCK) Epithelial Cells by Interfering with the Receptor-Smad Interaction. Journal of Biological Chemistry, 287(17):13705.
Chen YG# , Li, Z, Wang XF#.  (2012)  Where PI3K/Akt Meets Smads: The Crosstalk Determines Human Embryonic Stem Cell Fate. Cell Stem Cell, 10(3):231.(Review) (#Co-corresponding) .
Li Z and Chen YG#.  (2012) Fine-tune of intrinsic ERK activity by extrinsic BMP signaling in mouse embryonic stem cells. Protein Cell, 3(6):401-404. (Perspective)
Huang F, Chen YG#.   (2012)  Regulation of TGF-β Receptor Activity. Cell & Bioscience, 2012, 2:9 (Review).
Kua HY, Liu H, Leong WF, Li L, Jia D, Ma G, Hu Y, Wang X, Chau JFL, Chen YG, Mishina Y, Boast S, Yeh J, Xia L, Chen GQ, He L, Goff SP, Li B#.  (2012) c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression. Nature Cell Biology, 14(7):727.
Xiang H, Feng Y, Wang J, Liu B, Chen YG, Liu L, Deng X, Yang M#.  (2012) Crystal structures reveal the multi-ligand binding mechanism of Staphylococcus aureus ClfB. PLoS Pathogens, 8:e1002751.
Klionsky DJ,……..Chen YG……..(2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4):445-544. (Review)
Chau JFL, Jia D, Wang Z, Liu Z, Hu Y, Zhang X, Jia H, Lai KP, Leong WF, Au BJ, Mishina Y, Chen YG, Biondi C, Robertson E, Xie D, Liu H, He L, Wang X, Yu Q, Li B#.  (2012) A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response. Nature Communications, 3:836.
2011
Yan X, Zhang Y, Pan L, Wang P, Xue H, Zhang L, Gao X, Zhao X, Ning Y, Chen YG#.  (2011) TSC-22 promotes TGF-β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity. Molecular and Cellular Biology, 31(18):3700
Chen H, Liu L, Ma B, Ma M, Hou J, Xie G, Wu W, Yang F, Chen YG#.  (2011)  Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote Dishevelled degradation. Journal of Biological Chemistry,  286(17):14870
Tao R, Chen H, Gao C, Xue P, Yang F, Han JD, Zhou B, Chen YG#.   (2011)  Xbp1-mediated histone H4 deacetylation contributes to DNA double-strand break repair in yeast. Cell Research, 21(11):1619. 
Geng Y，Dong Y，Yu M，Zhang L，Yan X，Sun J，Qiao L，Geng H，Masahiro N，Tatsuya F，Shiro I， Gao X，Chen YG#，Jiang D# , Ning W#.  (2011)   Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proceedings of The National Academy of Sciences of The USA, 108(17):7058 (#Co-corresponding).
Gao C, Chen YG#.  (2011)  Selective removal of Dishevelled by autophagy: a role of p62, Autophagy, 7(3) 20. (Punctum).
Yan X, Chen YG#.  (2011)  Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signaling, Biochemical Journal, 434(1)1-10. (Review).
Xie Z, Chen Y, Li Z, Bai G, Zhu Y, Yan R, Tan F, Chen YG, Guillemot F, Li L, Jing N#. (2011) Smad6 promotes neuronal differentiation in the intermediate zone of the dorsal neural tube by inhibition of the Wnt/β-catenin pathway. Proc Natl Acad Sci. USA, 108:12119.
2010
Gao C, Cao W, Bao L, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG#.  (2010) Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation.  Nature Cell Biology，12(8):781
Fei T, Zhu S, Xia K, Zhang J, Li Z, Han JD#, Chen YG#.  (2010) Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells. Cell Research, 20:1306.
Zhang W, Yuan J, Yang Y, Xu L, Wang Q, Zuo W, Fang X#, Chen YG#.    (2010) Monomeric Type I and Type III Transforming Growth Factor-βReceptors and Their Dimerization. Cell Research, 20(11):1216.
Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han J#, Chen YG#. (2010) Genome-wide Mapping of SMAD Target Genes Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination. Genome Research,  20(1):36.
Wen J, Chiang YJ, Gao C, Xue H, Xu J, Ning Y, Hodes RJ, Gao X, Chen YG#.   (2010) Loss of Dact1 disrupts PCP signaling by altering Dishevelled activity and leads to posterior malformation in mice.  Journal of Biological Chemistry, 285(14):11023.
Gao C, Chen YG#.  (2010) Dishevelled: the hub of Wnt signaling. Cellular Signaling, 22(5): 717.(Review).
Fei T, Chen YG#.  (2010)  Regulation of embryonic stem cell self-renewal and differentiation by TGF-β family signaling. Science China Life Sciences, 53: 497. (Review)
Sun Y, Fei T, Yang T, Zhang F, Chen YG, Li H, Xu Z#. (2010) The suppression of CRMP2 expression by BMP-Smad gradient signaling controls multiple stages of neuronal development. Journal of Biological Chemistry, 285(50):39039.
Sheng N, Xie Z, Wang C, Zhang K, Zhu Q, Guillemot F, Chen YG, Lin A, Jing N#. (2010) Retinoic acid regulates bone morphorgenic protein signal duration by promoting the degradation of phosphorylated Smad1. Proceedings of The National Academy of Sciences of The USA, 107:18886.
Wang Y, Fu Y, Gao L, Zhu G, Liang J, Gao C, Huang B, Fenger U, Niehrs C, Chen YG, Wu W#. (2010) Xenopus Skip modulates Wnt/β-catenin signaling and functions in neural crest induction. Journal of Biological Chemistry, 285:10890.
Yu J, Pan L, Qin X, Chen H, Xu Y, Chen YG, Tang H#.  (2010) MTMR4 Attenuates TGF-β Signaling by Dephosphorylating R-Smads in Endosomes. Journal of Biological Chemistry, 285:8454.
2009
Zuo W, Chen YG#.  (2009) Specific activation of MAPK by TGF-β receptors in lipid rafts is required for epithelial cell plasticity.  Molecular Biology of the Cell, 20:1020
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG#. (2009) Human BAMBI cooperates with Smad7 to inhibit TGF-β Signaling. Journal of Biological Chemistry, 284:30097.
Zhang W, Jiang YX, Wang Q, Ma XY, Xiao ZY, Zuo W, Fang XH#, Chen YG#.   (2009) Single-molecule imaging reveals TGF-β induced type II receptor dimerization. Proceedings of the National Academy of Sciences, USA  106:15679.
Chen YG#, Wang XF#. (2009) Finale: the last minutes of Smads. Cell, 139:658-670. (Preview) (#Co-corresponding).
Yan X, Liu Z, Chen YG#.  (2009) Regulation of TGF-β signaling by Smad7. Acta Biochimica et Biophysica Sinica, 41(4):263-272.  (Review).
Chen YG#, Wang XF#.  (2009) A special issue on TGF-β signaling. Cell Research, 19:1-2.  (Editorial)(#Co-corresponding).
Chen YG#.  (2009) Endocytic regulation of TGF-β signaling. Cell Research, 19:58-70.  (Review).
Yan XH，Zhang JY, Chen YG#  (2009) Regulation of TGF-β Superfamily Signaling by Inhibitory Smads. Chinese Journal of Cell Biology，31(2):135-144. (Review).
2008
Gao X, Wen J, Zhang L, Li X, Ning Y, Meng A, Chen YG#.  (2008)  Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. Journal of Biological Chemistry, 283:35679
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG#. (2008) The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/β-catenin signaling. Journal of Biological Chemistry, 283:33053.
Zhao X, Nicholls JM, Chen YG#.  (2008) SARS-CoV nucleocapsid protein interacts with Smad3 and modulates TGF-β signaling. Journal of Biological Chemistry, 283:3272.
Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG#. (2008)  MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood, 111:588
Shi X, Chen F, Yu J, Xu Y, Zhang S, Chen YG, Fang X#. (2008) Study of interaction between Smad7 and DNA by single-molecule force spectroscopy. Biochemical and Biophysical Research Communications, 377:1284
2007
Zhang S, Fei T, Zhang L, Zhang R, Chen F, Ning Y, Han Y, Feng XH, Meng A, Chen YG#.  (2007) Smad7 antagonizes TGF-β signaling in the nucleus by interfering with functional Smad-DNA complex formation.  Molecular and Cellular Biology, 27:4488.
Ma J, Wang Q, Fei T, Han JD, Chen YG#. (2007) MCP-1 mediates TGF-β-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood, 109:987.
Huang W, Chang HY, Fei T, Wu H, Chen YG#.  (2007) GSK3β mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene, 26:2471.
Ma X, Wang Q, Jiang Y, Xiao Z, Fang X#, Chen YG#.  (2007) Lateral diffusion of TGF-β type I receptor studied by single-molecule imaging.  Biochemical and Biophysical Research Communications, 356:67.
Chen YG#, Wang Z, Ma J, Zhang L, Lu Z. (2007) Endofin, a FYVE domain protein, interacts with Smad4 and facilitates TGF-β signaling. Journal of Biological Chemistry, 282:9688.
Su Y, Zhang L, Gao X, Meng F, Wen J, Zhou H, Meng A#, Chen YG#. (2007)  The evolutionally conserved activity of Dapper2 in antagonizing TGF-β signaling.  FASEB Journal, 21:682.
Diao L, Chen YG#.  (2007) PTEN, a general negative regulator of cyclin D expression. Cell Research, 17:291-292.  (Review)
Gao X，Chen X, Chen YG#  (2007)  Progress in the research of Dapper in development and signaling pathway，Chinese Bulletin of Life Sciences， 19:471.
Yu J, Wang Q, Shi X, Ma X, Yang H, Chen YG, Fang X#. (2007) Single-molecule force spectroscopy study of interaction between transforming growth factor β and its receptor in living cells. Journal of Physical Chemistry B, 111:13619.
Lin X, Chen YG, Meng A, Feng XH#. (2007) Termination of TGF-β Superfamily Signaling Through SMAD Dephosphorylation-A Functional Genomic View.  Journal of Genetics and Genomics, 34(1): 1-9. (Review)
2006
Gu Y, Jin P, Zhang L, Zhao X, Gao X, Ning Y, Meng A, Chen YG#. (2006)  Functional analysis of mutations in the kinase domain of the TGF-β receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia.  Blood, 107:1951
Zhang L, Gao X, Wen J, Ning Y, Chen YG#.  (2006) Dapper 1 antagonizes Wnt signaling by promoting Dishevelled degradation.  Journal of Biological Chemistry, 281:8607.
Wu X, Ma J, Han JD, Wang N, Chen YG#.  (2006)  Distinct regulation of gene expression in human endothelial cells by TGF-β and its receptors.  Microvascular Research, 71:12.
Chen YG, Wang Q, Lin SL, Chang CD, Chung J, Ying SY#.(2006) Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis. Experimental Biology and Medicine (Maywood), 231(5):534-544. (Review)
Xia K, Xue H, Dong D, Zhu S, Wang J, Zhang Q, Hou L, Chen H, Tao R, Huang Z, Fu Z, Chen YG, Han JD#. (2006) Identification of the Proliferation/Differentiation Switch in the Cellular Network of Multicellular Organisms.  PLoS Computational Biology, 2:1482.
Liu W, Rui H, Wang J, Lin S, He Y, Chen M, Li Q, Ye Z, Zhang S, Chan SC, Chen YG, Han J, Lin SC#. (2006) Axin is a scaffold protein in TGF-β signaling that promotes degradation of Smad7 by Arkadia. EMBO Journal, 25:1646.
Xiong B, Rui Y, Zhang M, Shi K, Jia S, Tian T, Yin K, Huang H, Lin S, Zhao X, Chen Y, Chen YG, Lin SC, Meng A#. (2006) Tob1 Controls Dorsal Development of Zebrafish Embryos by Antagonizing Maternal β-Catenin Transcriptional Activity  Developmental Cell, 11:225.
Wang C, Xia C, Bian W, Liu L, Lin W, Chen YG, Ang SL, Jing N#. (2006)  Cell Aggregation-induced FGF8 Elevation Is Essential for P19 Cell Neural Differentiation.  Molecular Biology of Cell,  17:3075.
Sun Z, Jin P, Tian T, Gu Y, Chen YG, Meng A#.  2006  Activation and roles of ALK4/ALK7-mediated maternal TGF-β signals in zebrafish embryo. Biochemical and Biophysical Research Communications, 345:694.
Lin X, Duan X, Liang Y.Y., Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen YG., Meng A and Feng X#. (2006)  PPM1A functions as a Smad phosphatase to terminate TGF-β signaling.  Cell, 125:915.
2005
Li Z, Wang W, Zhou F, Gao X, Peng G, Xu H, Chen YG#. (2005) Interactions of Stathmin-like 2 protein with the APP intracellular domain.  Tsinghua Science and Technology, 10:484
Zhou FF，Li ZD，Wang WW，Liu R, Hong S, Xu HX，Chen YG#.  (2005) A Study of AID and Interacting Protein by Yeast Two-hybrid, Journal of Xiamen University, 44:299.
Wang WW，Li ZD，Liu R，Hong S，Xu HX，Chen YG#. (2005)  The Interaction of the Intracellular Domain of β-Amyloid Precursor Protein with JKTBP2。Acta Biologiae Experimentalis Sinica，38:164
Wang J, Xu N, Feng X, Hou N, Zhang J, Cheng X, Chen YG, Zhang Y, Yang X#.  2005  Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure.  Circulation Research, 97:821
2004
Zhang L, Zhou H, Su Y, Sun S, Zhang H, Zhang L, Zhang Y, Ning Y, Chen YG#, Meng A#. (2004)  Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114
Wang Z, Ren L, Zhao X, Hung T, Meng A, Wang J, Chen YG#.  (2004)  Inhibition of SARS virus replication by small interfering RNAs in mammalian cells. Journal of Virology, 78:7523.
Chen YG#, Meng A M#. (2004) Negative regulation of TGF-β signaling in development.  Cell Research, 14:441.(Review).
2003
Zhao XG, Han JD, Ning YH, Meng AM, Chen YG#. (2003)  Bioinformatics analysis of putative gene products encoded in SARS-HCoV genome. Tsinghua Science and Technology, 8:389
2002
Lu Z, Murray JT, Luo W, Li H, Wu X, Xu H, Backer JM, Chen YG#. (2002) Transforming growth factor β activates Smad2 in the absence of receptor endocytosis. Journal of Biological Chemistry, 277:29363
Chen YG, Liu HM, Lin SL, Lee JM, Ying SY  (2002)  Regulaiton of cell proliferation, apoptosis and carcinogenesis by activin. Experimental Biology and Medicine, 227:75.
2001
Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massague J#.  (2001) The TGF-β receptor acivation process: An inhibitor- to substrate-binding switch. Molecular Cell, 8:671
2000
Wu G*, Chen YG*, Ozdamar B, Gyuricza C, Chong PA, Wrana JL, Massagué J, Shi Y#.  (2000)  Structural basis of Smad2 recognition by the Smad Anchor for Receptor Activation. Science. 287:92-97. (*contributed equally) (Research Article)
Gouedard L, Chen, YG, Thevenet L, Racine C, Borie S, Lamarre I, Josso N, Massague J, di Clemente N#. (2000) Engagement of bone morphogenetic protein type IB receptor and Smad1 signaling by anti-Mullerian hormone and its type II receptor. Journal of Biological Chemistry, 275:27973.
Xu L, Chen YG, Massagué J#. (2000) The nuclear import function of Smad2 is masked by SARA and unmasked by TGF-β-dependent phosphorylation. Nature Cell Biology, 2:559.
Massagué J#, Chen YG. (2000) Controlling TGF-β signaling. Genes & Development, 14:627-644. (Review)
1999
Onichtchouk D*, Chen YG*, Dosch, R, Gawantka V, Delius H, Massagué J, Nierhs C#.  (1999)  Silencing of TGF-β signalling by the pseudoreceptor BAMBI.  Nature, 401:480-485. (*contributed equally)
Chen YG, Massagué J#. (1999) Smad1 recognition and activation by the ALK1 group of transforming growth factor-β family receptors.  Journal of Biological Chemistry, 274:3672.
Pasche B, Kolachana P, Nafa K, Satagopan J, Chen YG, Lo RS, Brener D, Yang D, Kirstein L, Oddoux C, Ostrer H, Vineis P, Varesco L, Jhanwar S, Luzzatto L, Massagué J, Offi K#. (1999) TβR-I(6A) is a candidate tumor susceptibility allele.  Cancer Research, 59:5678.
Huse M, Chen YG, Massagué J, Kuriyan J#. (1999) Crystal structure of the cytoplasmic domain of the type I TGF-β receptor in complex with FKPB12.  Cell, 96:425.
1998
Chen YG*, Hata A*, Lo RS, Wotton D, Shi Y, Pavletich NP, Massagué J#.  (1998) Determinants of specificity in TGF-β signal transduction.  Genes & Development, 12:2144. 
Lo RS*, Chen YG*, Shi Y, Pavletich NP, Massagué J#. (1998) The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-β receptors. EMBO Journal, 17:996-1005. (*contributed equally)
1997
Chen YG, Siddhanta A, Austin CD, Hammond SM, Sung TC, Frohman MA, Morris AJ, Shields D#.  (1997) Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network.  Journal of Cell Biology, 138:495.
Chen YG, Liu F, Massagué J#.  1997 Mechanism of TGF-β receptor inhibition by FKBP12.  EMBO Journal, 16:3866
1996
Chen YG, Shields D#.  (1996) ADP-ribosylation factor-1 stimulates formation of nascent secretory vesicles from the trans-Golgi network of endocrine cells.  Journal of Biological Chemistry, 271:5297
1995
Chen YG, Danoff A, Shields D#. (1995) The propeptide of Anglerfish preprosomatostatin-I rescues prosomatostatin-II from intracellular degradation.  Journal of Biological Chemistry, 270:18598.
1990
Davis GM, Liu YY, Chen YG. (1990) New genus of Triculinae (Prosobranchia: Promatiopsidae) from China: phylogenetic relationships.  Proceedings of the Academy of Natural Sciences of Philadelphia, 142:143
1988
Chen YG.  (1988)  The Biology of the Freshwater Snail Parafossarulus Eximius，Acta Hydrobiologica Sinica， 12 (2): 97.
Chen YG.  (1988)  Freshwater Snails in Poyang Lake and Its Surrouding Waters，Zoological Bulletin， 6:69.